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Shakingheadachediarrheanausea/vomitingupset stomachloss of appetitetrouble sleepingand tingling of the hands/feet may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

The data in kidney transplant patients indicate that the Black patients required a higher dose to attain comparable trough concentrations compared to Caucasian patientsTable 2

ISMP Canada received a report of a medication incident in which Advagrafan extended-release formulation of tacrolimus for oral administrationwas dispensed to a patient instead of the intended Prografan immediate-release oral formulation of the same drugRecent reports from the United Kingdom 12 and Europe 34 have documented mix-ups between Prograf and Advagraf and have outlined concerns about the outcomes of such incidentsAccording to these warningsmix-ups between Prograf and Advagraf have led to serious harmincluding cases of biopsy-confirmed acute rejection of transplanted organs and toxic effects due to overexposureAlthough this incident occurred in a community pharmacyit is an important alert for hospital pharmacists about the potential for serious patient harm if these drugs are mistakenly interchanged.

Change in your mental stateproblems with speech or walkingdecreased visionmay start gradually and get worse quickly

Since this drug can be absorbed through the skin and lungs and may harm an unborn babywomen who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

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you are allergic to any ingredient in prograf, including castor oil you are taking astemizole, cisapride, dofetilide, ibutilide, a potassium-sparing diuretic eg, spironolactone , sirolimus, terfenadine, or ziprasidone you have taken cyclosporine with the last 24 hours.

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